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My cardiologist diagnosed me with stable angina about a year ago. At that time I experienced tightness in my chest and pain when breathing after some exercises. That considerable spoiled my life as I enjoy climbing and often stay in the mountains with my friends. He put me on some medication and the on second day of taking it I developed some itching and rash on my arms. However I decided that was from mosquitoes or some strange food and paid no attention and naturally continued on the medication. The rash wouldn't disappear and having come back home I visited a dermatologist. He said it was not a skin disorder and probably some intolerance of a new drug. I went to the cardiologist again and he told me to stop taking the medication and prescribed Ranolazine. With this med I had no itching or rash. The angina also created considerably less problems that before. No I could control the pain and had no more problems with breathing. It's been two months since I have started on Ranolazine and I am absolutely ok with it.

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Renal insufficiency includes both acute and chronic renal failure, including end-stage renal disease (ESRD).

Small, reversible elevations in serum creatinine and BUN levels have been observed in clinical studies with ranolazine.

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This animation (with audio) illustrates the mechanism of action of ranolazine (RANEXA), a novel antianginal drug that inhibits the late sodium current (late I Na) in cardiac myocytes.

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The benefit in patients with unstable angina is less clear.

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This image of the FDA label is provided by the National Library of Medicine.

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In a separate study, Cmax was increased between 40% and 50% in patients with mild, moderate or severe renal impairment compared to patients with no renal impairment, suggesting a similar increase in exposure in patients with renal failure independent of the degree of impairment.

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The external blind peer reviewers report no conflicts of interest.

Changes in antianginal medical therapy likely to occur during the study period.

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An acute increase in cardiac work load generally increases myocardial fatty acid uptake and β-oxidation.

The researchers also found that ranolazine was especially effective in patients with worse glucose control, as measured by hemoglobin a1c (Hba1c) levels.

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Unstable angina usually is related to the rupture of an atherosclerotic plaque and the abrupt narrowing or occlusion of a coronary artery, representing a medical emergency with an incipient acute coronary syndrome and an MI to follow.

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The objective of the ERICA (Efficacy of Ranolazine In Chronic Angina) trial was to specifically examine the antianginal efficacy of ranolazine when used with maximum recommended doses of amlodipine.

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Treadmill exercise testing at peak and trough plasma levels was performed after 2, 6 (trough only), and 12 weeks of treatment.

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In addition, relaxation techniques, mental focusing strategies, guided imagery, and yoga have all proven useful in reducing stress for patients with coronary artery disease.

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The concept of a revascularization benefit in patients with extended ischaemia is currently being tested in the ongoing International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA).

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Fast treatment gives the best outcome for all myocardial infarctions.

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Different Na channel isoforms have been characterized and codenamed Na v1.

Several randomized controlled trials (RCTs) have supported the use of ranolazine in this population.

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